Description
Simbrinza Eye Drops 5ml Specification
Requires Prescription (YES/NO)
Yes
Generics
Brinzolamide , Brimonidine tartrate
Used For
Glaucoma
How it works
It contains two active substances: brinzolamide and brimonidine tartrate. These two components lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT) by suppressing the formation of aqueous humour from the ciliary process in the eye. Although both brinzolamide and brimonidine lower IOP by suppressing aqueous humour formation, their mechanisms of action are different.Brinzolamide acts by inhibiting the enzyme carbonic anhydrase (CA-II) in the ciliary epithelium that reduces the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport across the ciliary epithelium, resulting in decreased aqueous humour formation. Brimonidine, an alpha-2 adrenergic agonist, inhibits the enzyme adenylate cyclase and suppresses the cAMP-dependent formation of aqueous humour. Additionally, administration of brimonidine results in an increase in uveoscleral outflow.
Usage And Safety
Dosage
Adults : 1 drop in the affected eye two or three times daily . Children : <2yrs : Not Recommended . OR As directed by your physician.
Side Effects
Somnolence , dermatitis , dry throat , hypotension , vertigo , blurred vision , bad taste .
Drug Interactions
MAOIs , oral carbonic anhydrase inhibitors , high-dose salicylate therapy , CNS depressants , antihypertensives/cardiac glycosides , tricyclic antidepressants .
Indication
It is used to lower pressure in the eyes in adult patients (aged 18 years and over) who have eye conditions known as glaucoma or ocular hypertension and whose high pressure in the eyes cannot be controlled effectively by one medicine alone.
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